Explore our extensive range of publications in peer reviewed journals
N-myristoyltransferase biology
High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation. Dian C, Pérez-Dorado I, Rivière F, Asensio T, Legrand P, Ritzefeld M, Shen M, Cota E, Meinnel T, Tate EW, Giglione C. Nat Commun. 2020 Feb 28;11(1):1132.
Acylation-coupled lipophilic induction of polarisation (Acyl-cLIP): a universal assay for lipid transferase and hydrolase enzymes. Lanyon-Hogg T, Ritzefeld M, Sefer L, Bickel JK, Rudolf AF, Panyain N, Bineva-Todd G, Ocasio CA, O’Reilly N, Siebold C, Magee AI, Tate EW. Chem Sci. 2019 Jul 1;10(39):8995-9000
Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors. Schlott AC, Mayclin S, Reers AR, Coburn-Flynn O, Bell AS, Green J, Knuepfer E, Charter D, Bonnert R, Campo B, Burrows J, Lyons-Abbott S, Staker BL, Chung CW, Myler PJ, Fidock DA, Tate EW, Holder AA. Cell Chem Biol. 2019 Jul 18;26(7):991-1000.e7. doi: 10.1016/j.chembiol.2019.03.015. Epub 2019 May 9.
Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases. Kallemeijn WW, Lueg GA, Faronato M, Hadavizadeh K, Goya Grocin A, Song OR, Howell M, Calado DP, Tate EW. Cell Chem Biol. 2019 Jun 20;26(6):892-900.e4
Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics. Storck EM, Morales-Sanfrutos J, Serwa RA, Panyain N, Lanyon-Hogg T, Tolmachova T, Ventimiglia LN, Martin-Serrano J, Seabra MC, Wojciak-Stothard B, Tate EW. Nat Chem. 2019 Jun;11(6):552-561. doi: 10.1038/s41557-019-0237-6.
Whole Proteome Profiling of N-Myristoyltransferase Activity and Inhibition Using Sortase A. Goya Grocin A, Serwa RA, Morales Sanfrutos J, Ritzefeld M, Tate EW. Mol Cell Proteomics. 2019 Jan;18(1):115-126. doi: 10.1074/mcp.RA118.001043. Epub 2018 Oct 19.
N-Myristoylation as a Drug Target in Malaria: Exploring the Role of N-Myristoyltransferase Substrates in the Inhibitor Mode of Action. Schlott AC, Holder AA, Tate EW. ACS Infect Dis. 2018 Apr 13;4(4):449-457
Dynamic Protein Acylation: New Substrates, Mechanisms, and Drug Targets. Lanyon-Hogg T, Faronato M, Serwa RA, Tate EW. Trends Biochem Sci. 2017 Jul;42(7):566-581
Photoactivatable Myristic Acid Probes for UNC119-Cargo Interactions. Kaiser N, Mejuch T, Fedoryshchak R, Janning P, Tate EW, Waldmann H. Chembiochem. 2019 Jan 18;20(2):134-139.
Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase. Yu Z, Brannigan JA, Rangachari K, Heal WP, Wilkinson AJ, Holder AA, Leatherbarrow RJ, Tate EW. Medchemcomm. 2015 Oct 8;6(10):1767-1772.
Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase. Rackham MD, Yu Z, Brannigan JA, Heal WP, Paape D, Barker KV, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW. Medchemcomm. 2015 Oct 8;6(10):1761-1766.
Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. Thinon E, Serwa RA, Broncel M, Brannigan JA, Brassat U, Wright MH, Heal WP, Wilkinson AJ, Mann DJ, Tate EW. Nat Commun. 2014 Sep 26;5:4919.
Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors. Hutton JA, Goncalves V, Brannigan JA, Paape D, Wright MH, Waugh TM, Roberts SM, Bell AS, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW. J Med Chem. 2014 Oct 23;57(20):8664-70.
Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach.Wright MH, Clough B, Rackham MD, Rangachari K, Brannigan JA, Grainger M, Moss DK, Bottrill AR, Heal WP, Broncel M, Serwa RA, Brady D, Mann DJ, Leatherbarrow RJ, Tewari R, Wilkinson AJ, Holder AA, Tate EW. Nat Chem. 2014 Feb;6(2):112-21.
The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms. Greasley SE, Jhoti H, Teahan C, Solari R, Fensome A, Thomas GM, Cockcroft S, Bax B. Nat Struct Biol. 1995 2(9):797-806
Oncology
Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors.Howard RT, Hemsley P, Petteruti P, Saunders CN, Molina Bermejo JA, Scott JS, Johannes JW, Tate EW. ACS Chem Biol. 2020 Feb 21;15(2):325-333.
Recent Developments in Cell Permeable Deubiquitinating Enzyme Activity-Based Probes. Conole D, Mondal M, Majmudar JD, Tate EW. Front Chem. 2019 Dec 18;7:876
FSP1 is a glutathione-independent ferroptosis suppressor. Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, Grocin AG, Xavier da Silva TN, Panzilius E, Scheel CH, Mourão A, Buday K, Sato M, Wanninger J, Vignane T, Mohana V, Rehberg M, Flatley A, Schepers A, Kurz A, White D, Sauer M, Sattler M, Tate EW, Schmitz W, Schulze A, O’Donnell V, Proneth B, Popowicz GM, Pratt DA, Angeli JPF, Conrad M. Nature. 2019 Nov;575(7784):693-698.
The molecular function of kallikrein-related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer. Kryza T, Bock N, Lovell S, Rockstroh A, Lehman ML, Lesner A, Panchadsaram J, Silva LM, Srinivasan S, Snell CE, Williams ED, Fazli L, Gleave M, Batra J, Nelson C, Tate EW, Harris J, Hooper JD, Clements JA. Mol Oncol. 2020 Jan;14(1):105-128.
Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions. Birtley JR, Alomary M, Zanini E, Antony J, Maben Z, Weaver GC, Von Arx C, Mura M, Marinho AT, Lu H, Morecroft EVN, Karali E, Chayen NE, Tate EW, Jurewicz M, Stern LJ, Recchi C, Gabra H. Nat Commun. 2019 Jul 17;10(1):3134. doi: 10.1038/s41467-019-10966-8.
Imaging of Chemotherapy-Induced Acute Cardiotoxicity with 18F-Labeled Lipophilic Cations. McCluskey SP, Haslop A, Coello C, Gunn RN, Tate EW, Southworth R, Plisson C, Long NJ, Wells LA. J Nucl Med. 2019 Dec;60(12):1750-1756. doi: 10.2967/jnumed.119.226787. Epub 2019 May 30
Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer. Wang Z, Grosskurth SE, Cheung T, Petteruti P, Zhang J, Wang X, Wang W, Gharahdaghi F, Wu J, Su N, Howard RT, Mayo M, Widzowski D, Scott DA, Johannes JW, Lamb ML, Lawson D, Dry JR, Lyne PD, Tate EW, Zinda M, Mikule K, Fawell SE, Reimer C, Chen H. Cancer Res. 2018 Dec 1;78(23):6691-6702.
Mouse Stbd1 is N-myristoylated and affects ER-mitochondria association and mitochondrial morphology. Demetriadou A, Morales-Sanfrutos J, Nearchou M, Baba O, Kyriacou K, Tate EW, Drousiotou A, Petrou PP. J Cell Sci. 2017 Mar 1;130(5):903-915.
Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells. Rodgers UR, Lanyon-Hogg T, Masumoto N, Ritzefeld M, Burke R, Blagg J, Magee AI, Tate EW. ACS Chem Biol. 2016 Dec 16;11(12):3256-3262
N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells. Thinon E, Morales-Sanfrutos J, Mann DJ, Tate EW. ACS Chem Biol. 2016 Aug 19;11(8):2165-76
Virology
Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain. Benfield CT, MacKenzie F, Ritzefeld M, Mazzon M, Weston S, Tate E, Teo BH, Smith SE, Kellam P, Holmes EC, Marsh M. Life Sci Alliance. 2019 Dec 11;3(1). pii: e201900542.
Analysis of a fully infectious bio-orthogonally modified human virus reveals novel features of virus cell entry. Serwa RA, Sekine E, Brown J, Teo SHC, Tate EW, O’Hare P. PLoS Pathog. 2019 Oct 7;15(10):e1007956. doi: 10.1371/journal.ppat.1007956. eCollection 2019 Oct.
Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus. Mousnier A, Bell AS, Swieboda DP, Morales-Sanfrutos J, Pérez-Dorado I, Brannigan JA, Newman J, Ritzefeld M, Hutton JA, Guedán A, Asfor AS, Robinson SW, Hopkins-Navratilova I, Wilkinson AJ, Johnston SL, Leatherbarrow RJ, Tuthill TJ, Solari R, Tate EW. Nat Chem. 2018 Jun;10(6):599-606.
Lanosterol Synthase Regulates Human Rhinovirus Replication in Human Bronchial Epithelial Cells. McCrae C, Dzgoev A, Ståhlman M, Horndahl J, Svärd R, Große A, Großkopf T, Skujat MA, Williams N, Schubert S, Echeverri C, Jackson C, Guedán A, Solari R, Vaarala O, Kraan M, Rådinger M. Am J Respir Cell Mol Biol. 2018 Dec;59(6):713-722.
Host lipidome analysis during rhinovirus replication in HBECs identifies potential therapeutic targets. Nguyen A, Guedán A, Mousnier A, Swieboda D, Zhang Q, Horkai D, Le Novere N, Solari R, Wakelam MJO. J Lipid Res. 2018 Sep;59(9):1671-1684.
Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations. Singanayagam A, Glanville N, Girkin JL, Ching YM, Marcellini A, Porter JD, Toussaint M, Walton RP, Finney LJ, Aniscenko J, Zhu J, Trujillo-Torralbo MB, Calderazzo MA, Grainge C, Loo SL, Veerati PC, Pathinayake PS, Nichol KS, Reid AT, James PL, Solari R, Wark PAB, Knight DA, Moffatt MF, Cookson WO, Edwards MR, Mallia P, Bartlett NW, Johnston SL. Nat Commun. 2018 Jun 8;9(1):2229
Cytokine Responses to Rhinovirus and Development of Asthma, Allergic Sensitization, and Respiratory Infections during Childhood. Custovic A, Belgrave D, Lin L, Bakhsoliani E, Telcian AG, Solari R, Murray CS, Walton RP, Curtin J, Edwards MR, Simpson A, Rattray M, Johnston SL. Am J Respir Crit Care Med. 2018 May 15;197(10):1265-1274
Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation. Toussaint M, Jackson DJ, Swieboda D, Guedán A, Tsourouktsoglou TD, Ching YM, Radermecker C, Makrinioti H, Aniscenko J, Bartlett NW, Edwards MR, Solari R, Farnir F, Papayannopoulos V, Bureau F, Marichal T, Johnston SL. Nat Med. 2017 Jun;23(6):681-691
Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication. Guedán A, Swieboda D, Charles M, Toussaint M, Johnston SL, Asfor A, Panjwani A, Tuthill TJ, Danahay H, Raynham T, Mousnier A, Solari R. J Virol. 2017 Apr 13;91(9).
Human rhinovirus 16 causes Golgi apparatus fragmentation without blocking protein secretion. Mousnier A, Swieboda D, Pinto A, Guedán A, Rogers AV, Walton R, Johnston SL, Solari R. J Virol. 2014 Oct;88(20):11671-85
The application of prophylactic antibodies for rhinovirus infections. Privolizzi R, Solari R, Johnston SL, McLean GR. Antivir Chem Chemother. 2014 Apr 11;23(5):173-7
Science
Based on world leading research into the structure and biology of N-myristoyltransferase (NMT), the key enzyme in protein myristoylation.
